A recent report in JAMA Internal Medicine elicited great interest with clinicians, endocrinologists, and toxicologists. The authors' key finding was that 3-phenoxybenzoic acid, the main metabolite of numerous pyrethroid insecticides, increased risk of mortality from all causes and specifically, death from cardiovascular disease in the US adult population. This finding was surprising because pyrethroids have low acute mammalian toxicity in comparison with the previous classes of pesticides, mainly organophosphates, which pyrethroids largely replaced in the 1980s.

中文翻译：

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拟除虫菊酯暴露：毕竟不是那么无害。

JAMA Internal Medicine最近的一份报告引起了临床医生、内分泌学家和毒理学家的极大兴趣。作者的主要发现是，许多拟除虫菊酯杀虫剂的主要代谢物 3-苯氧基苯甲酸会增加美国成年人群因各种原因导致的死亡风险，特别是心血管疾病导致的死亡风险。这一发现令人惊讶，因为与之前类别的杀虫剂（主要是有机磷）相比，拟除虫菊酯对哺乳动物的急性毒性较低，在 1980 年代，拟除虫菊酯在很大程度上取代了有机磷农药。