Guidelines recommend that appropriate information about the effects of cancer treatment on ovarian function and future fertility should be provided to all paediatric patients and their families. ^,  Although fertility counselling in children and adolescents is more complex than in adults, the risk of acute ovarian failure, defined as permanent discontinuation of menstruation within 5 years of diagnosis or primary amenorrhoea, is a major concern in this population because it affects long-term quality of life. The evaluation of this risk is often difficult in young patients and prospective studies are scarce. The Childhood Cancer Survivor Study (CCSS) provided important data leading to estimates that the overall prevalence of acute ovarian failure in survivors of childhood cancer is 6%. The occurrence of this side-effect varies greatly according to the type and dose of treatment, the disease, and the age of the child at diagnosis. Children and adolescents treated with high doses of alkylating drugs, haematopoietic stem-cell transplantation, or pelvic irradiation are considered to be at high risk (>80%) of future poor fertility. Although risk factors have been previously identified, access to accurate and easy-to-use models for predicting future risk of acute ovarian failure remains an unmet need, affecting the decision of whether or not to offer fertility preservation procedures to children and adolescents with cancer.

中文翻译：

---

为儿童癌症幸存者提供生育保护咨询。

指南建议，应向所有儿科患者及其家人提供有关癌症治疗对卵巢功能和未来生育能力影响的适当信息。^， 尽管儿童和青少年的生育咨询比成人要复杂，但是急性卵巢衰竭的风险（定义为诊断后5年内永久性月经中断或原发性闭经）是该人群中的主要问题，因为它会影响长期质量生活。在年轻患者中，这种风险的评估通常很困难，并且前瞻性研究很少。儿童癌症幸存者研究（CCSS）提供了重要数据，据此估算，儿童癌症幸存者中急性卵巢衰竭的总体患病率为6％。根据治疗的类型和剂量，疾病以及诊断时儿童的年龄，这种副作用的发生有很大不同。用高剂量烷基化药物治疗的儿童和青少年，造血干细胞移植，或盆腔放疗被认为将来生育能力差的高风险（> 80％）。尽管以前已经确定了危险因素，但仍无法满足需要精确且易于使用的模型来预测未来急性卵巢衰竭的风险，这影响了是否为患有癌症的儿童和青少年提供生育力保留程序的决定。