The use of antibiotics during pregnancy is associated with increased allergic asthma risk in the offspring, and given that approximately 25% of pregnant women are prescribed antibiotics, it is important to understand the mechanisms contributing to this phenomenon. Currently, there are no studies that directly test this association experimentally. Our objective was to develop a mouse model in which antibiotic treatment during pregnancy results in increased offspring asthma susceptibility.

中文翻译：

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怀孕期间使用抗生素会以剂量依赖性方式增加后代哮喘的严重程度

怀孕期间使用抗生素与后代过敏性哮喘风险增加有关，鉴于大约 25% 的孕妇服用抗生素，了解导致这种现象的机制很重要。目前，没有研究直接通过实验测试这种关联。我们的目标是开发一种小鼠模型，在该模型中，怀孕期间的抗生素治疗会增加后代的哮喘易感性。