Covering: Up to 2020Ion channels are a vast super-family of membrane proteins that play critical physiological roles in excitable and non-excitable cells. Their biomedical importance makes them valuable and attractive drug targets for neurological, cardiovascular, gastrointestinal and metabolic diseases, and for cancer therapy and immune modulation. Current therapeutics target only a minor subset of ion channels, leaving a large unexploited space within the ion channel field. Natural products harnessed from the almost unlimited and diverse universe of compounds within the bioenvironment have been used to modulate channels for decades. In this review we highlight the impact made by natural products on ion channel pharmacology, specifically on K+, NaV and CaV channels, and use case studies to describe the development of ion channel-modulating drugs from natural sources for the treatment of pain, heart disease and autoimmune diseases.

中文翻译：

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天然产物对离子通道药理的贡献。

覆盖范围：截至2020年，离子通道是一个庞大的膜蛋白超家族，在兴奋性和非兴奋性细胞中起关键的生理作用。它们的生物医学重要性使其成为神经，心血管，胃肠道和代谢性疾病以及癌症治疗和免疫调节的有价值且有吸引力的药物靶标。当前的治疗剂仅靶向离子通道的一小部分，在离子通道场内留下未利用的大空间。从生物环境中几乎无限和多样化的化合物中提取的天然产物已用于调节通道数十年。在这篇评论中，我们重点介绍了天然产物对离子通道药理学的影响，特别是对K +，NaV和CaV通道的影响，