Purpose

The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. The PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on renal MRI.

Methods

A task force was formed in July 2018 focused on five methods. A draft process for attaining consensus was distributed publicly for consultation and finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between October 2018 and March 2019, discussed results and refined the surveys at a face-to-face meeting (Aarhus, March 2019) and completed a second round (May 2019).

Results

A seven-stage process was defined: (1) formation of expert panels; (2) definition of the context of use; (3) literature review; (4) collection and comparison of MRI protocols; (5) consensus generation by an approximate Delphi method; (6) reporting of results in vendor-neutral and vendor-specific terms; (7) ongoing review and updating. Application of the process resulted in 166 consensus statements.

Conclusion

The process generated meaningful technical recommendations across very different MRI methods, while allowing for improvement and refinement as open issues are resolved. The results are likely to be widely supported by the renal MRI community and thereby promote more harmonisation.

中文翻译：

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肾MRI的临床翻译技术建议：科学与技术行动合作组织（PARENCHIMA）的共识项目

目的

肾脏MRI生物标记物的潜力已得到越来越多的认识，但是临床翻译需要更多的标准化。PARENCHIMA共识项目旨在开发和应用一种程序，以产生有关肾脏MRI的技术建议。

方法

2018年7月成立了一个工作组，重点研究五种方法。公开发布了达成共识的流程草案以征询意见，并在一次公开会议（2018年10月，布拉格）上定稿。四个专家小组在2018年10月至2019年3月之间完成了调查，讨论了结果并在面对面会议（奥胡斯，2019年3月）上完善了调查，并完成了第二轮（2019年5月）。

结果

定义了七个阶段的过程：（1）组建专家小组；（2）使用范围的定义；（3）文献综述；（4）MRI方案的收集与比较；（5）通过近似德尔菲法生成共识；（6）以与供应商无关和特定于供应商的术语报告结果；（7）持续审查和更新。该程序的应用产生了166个共识声明。

结论

该过程在非常不同的MRI方法中产生了有意义的技术建议，同时随着未解决的问题得到解决，可以进行改进和完善。肾脏MRI社区可能会广泛支持该结果，从而促进更多的协调。