Abstract Two metal complexes, [Zn(bmbp)Cl 2 ]·H 2 O ( 1 ) and [Co(bmbp) 2 ](ClO 4 ) 2 ·DMF·H 2 O ( 2 ) (bmbp = 4-benzyloxy-2,6-bis(1-methyl-2-benzimidazolyl)pyridine), have been synthesized and characterized. X-ray crystal structure analysis for complex 1 reveals that the Zn(II) atom is penta-coordinated with three nitrogen atoms of the ligand and two chlorine atoms in the coordination sphere, adopting a distorted square pyramidal geometry. For complex 2 , the central Co(II) atom is bonded by six nitrogen atoms from two ligands in a distorted octahedral fashion. The two complexes feature 1D chain structures generated by C–H⋯π interactions. The thermal stabilities and spectroscopic properties of the complexes have been studied. Both complexes exhibit inhibition on the growth of the Eca109 cancer cells, but show lower antitumor activity than cisplatin. Graphic Abstract Two zinc(II) and cobalt(II) complexes based on 4-benzyloxy-2,6-bis(1-methyl-2-benzimidazolyl)pyridine, which exhibit inhibition on the growth of Eca109 cancer cell, were synthesized and characterized by X-ray single crystal structure analysis.

中文翻译：

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衍生自 4-Benzyloxy-2,6-bis(1-methyl-2-benzimidazolyl)pyridine 的锌 (II) 和钴 (II) 配合物：合成、晶体结构、光谱特性和抗肿瘤活性

摘要 两种金属配合物[Zn(bmbp)Cl 2 ]·H 2 O ( 1 ) 和[Co(bmbp) 2 ](ClO 4 ) 2 ·DMF·H 2 O ( 2 ) (bmbp = 4-benzyloxy-2 ,6-双(1-甲基-2-苯并咪唑基)吡啶), 已合成和表征。配合物 1 的 X 射线晶体结构分析表明，Zn(II) 原子与配体的三个氮原子和配位球中的两个氯原子呈五配位，采用扭曲的四角锥几何形状。对于配合物 2，中心的 Co(II) 原子由来自两个配体的六个氮原子以扭曲的八面体方式键合。这两个复合物具有由 C–H⋯π 相互作用产生的一维链结构。已经研究了配合物的热稳定性和光谱性质。两种复合物均表现出对 Eca109 癌细胞生长的抑制作用，但抗肿瘤活性低于顺铂。图形摘要 合成并表征了两种基于 4-苄氧基-2,6-双（1-甲基-2-苯并咪唑基）吡啶的锌（II）和钴（II）配合物，它们对 Eca109 癌细胞的生长具有抑制作用通过 X 射线单晶结构分析。