DNA exhibits many attractive properties, such as programmability, precise self-assembly, sequence-coded biomedical functions, and good biocompatibility; therefore, DNA has been used extensively as a building block to construct novel nanomaterials. Recently, studies on oligonucleotide-polymer conjugates (OPCs) have attracted increasing attention. As hybrid molecules, OPCs exhibit novel properties, e.g., sophisticated self-assembly behaviors, which are distinct from the simple combination of the functions of DNA and polymer, making OPCs interesting and useful. The synthesis and applications of OPCs are highly dependent on the choice of the polymer block, but a systematic summary of OPCs based on their molecular structures is still lacking. In order to design OPCs for further applications, it is necessary to thoroughly understand the structure-function relationship of OPCs. In this review, we carefully categorize recently developed OPCs by the structures of the polymer blocks, and discuss the synthesis, purification, and applications for each category. Finally, we will comment on future prospects for OPCs.

中文翻译：

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寡核苷酸-聚合物缀合物：从分子基础到实际应用。

DNA具有许多吸引人的特性，例如可编程性，精确的自组装，序列编码的生物医学功能以及良好的生物相容性。因此，DNA已被广泛用作构建新型纳米材料的基础。最近，对寡核苷酸-聚合物共轭物（OPC）的研究已引起越来越多的关注。作为杂化分子，OPC具有新颖的特性，例如复杂的自组装行为，这与DNA和聚合物功能的简单组合不同，这使OPC变得有趣而有用。OPC的合成和应用高度依赖于聚合物嵌段的选择，但是仍然缺乏基于OPC分子结构的系统总结。为了设计OPC以进一步应用，有必要彻底了解OPC的结构功能关系。在这篇综述中，我们根据聚合物嵌段的结构对最新开发的OPC进行了仔细分类，并讨论了每种类别的合成，纯化和应用。最后，我们将对OPC的未来前景发表评论。