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Hybrid femtosecond laser fabrication of a size-tunable microtrap chip with a high-trapping retention rate.
Optics Letters ( IF 3.6 ) Pub Date : 2020-03-01 , DOI: 10.1364/ol.386095
Bing Xu , Shengyun Ji , Deng Pan , Wenjin Hu , Suwan Zhu , Yanlei Hu , Jiawen Li , Dong Wu , Jiaru Chu , Koji Sugioka

In this Letter, we propose a new (to the best of our knowledge), promising concept of a hybrid femtosecond (fs) laser processing method composed of single-point scanning and holographic light modulation fabrication for manufacturing a tunable-size microtrap chip. The hybrid method not only ensures key microfluidic device precision but also greatly improves the fabrication speed. By using a new asymmetry-bracket-shaped microtrap design with a mechanical strain stretching method, real-time size-tunable trapping is obtained, and a 100% particle trapping retention is realized, ignoring the flow fluctuation. Finally, the microtrap array is successfully applied to trap single yeast cells and hold them for $\sim{10}\;{\rm h}$∼10h without escaping.

中文翻译:

具有高陷阱保留率的尺寸可调微陷阱芯片的混合飞秒激光制造。

在这封信中,我们提出了一种新的(据我们所知)充满希望的混合飞秒(fs)飞秒激光加工方法的概念,该方法由单点扫描和全息光调制制造构成,用于制造可调大小的微阱芯片。混合方法不仅可以确保关键的微流控设备的精度,而且可以大大提高制造速度。通过使用具有机械应变拉伸方法的新型不对称支架形微阱设计,可以获得实时的尺寸可调捕集,并且实现了100%的颗粒捕集保留率,而无需考虑流量波动。最终,微阱阵列成功地用于捕获单个酵母细胞,并在不逃逸的情况下将它们保持$ \ sim {10} \; {\ rm h} $〜10h。
更新日期:2020-02-28
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