A series of diiron complexes based on the [Fe₂Cp₂(CO)_x] skeleton (Cp = η⁵-C₅H₅, x = 2, 3; η⁴-C₅H₅Ph in place of one Cp in one case) and containing different bridging hydrocarbyl ligands (aminocarbyne, thiocarbyne, allenyl) were preliminarily investigated for their anticancer potential. The water solubility, stability in water and in the presence of a cell culture medium, and octanol/water partition coefficient were evaluated by spectroscopic techniques. The cytotoxicity was assessed in vitro toward the human ovarian carcinoma cell line A2780, the human triple negative breast cancer cell line MDA-MB-231, and the human vascular smooth muscle cell line SMC. Some aminocarbyne complexes exhibited a potent cytotoxicity, with IC₅₀ values in the low micromolar/nanomolar range, and a strong selectivity for the A2780 cells in comparison to the SMC cell line. Several experiments were carried out in order to give insight into the mode of action of selected compounds, including an assessment of catalytic NADH oxidation and ROS production and studies of binding with DNA and with a model protein.

中文翻译：

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探索与桥联烃基配体的二价铁双-双环戊二烯基复合物的抗癌潜力：在水介质中的行为和体外细胞毒性。

基于A系列二铁配合物的[Fe ₂的Cp ₂（CO）_X ]骨架（CP =η ⁵ -C ₅ H ^ ₅，X = 2，3;η ⁴ -C ₅ ħ ₅博士代替一个Cp的在初步研究了含有不同桥联烃基配体（氨基碳炔，硫代碳炔，烯丙基）的抗癌潜力。通过光谱技术评估水溶性，在水中和在细胞培养基存在下的稳定性以及辛醇/水分配系数。在体外评估细胞毒性针对人卵巢癌细胞系A2780，人三阴性乳腺癌细胞MDA-MB-231和人血管平滑肌细胞系SMC。与SMC细胞系相比，某些氨基碳炔复合物表现出强的细胞毒性，IC ₅₀值在低微摩尔/纳摩尔范围内，并且对A2780细胞具有很强的选择性。为了了解所选化合物的作用方式，进行了一些实验，包括评估催化NADH氧化和ROS的产生，以及研究与DNA和模型蛋白的结合。