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Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases.
Cellular and Molecular Life Sciences ( IF 7.014 ) Pub Date : 2020-02-15 , DOI: 10.1007/s00018-020-03475-1
Dong Wang,Redouane Tabti,Sabria Elderwish,Hussein Abou-Hamdan,Amel Djehal,Peng Yu,Hajime Yurugi,Krishnaraj Rajalingam,Canan G Nebigil,Laurent Désaubry

Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and neurodegenerative diseases. This review provides an updated overview of the various classes of PHB ligands, with an emphasis on their mechanism of action and therapeutic potential. We also describe how these ligands have been used to explore PHB signaling in different physiological and pathological settings.
更新日期:2020-02-18

 

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