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The Subacute Toxicity of Perfluorooctane Sulfonate and/or Perfluorooctanoic Acid and Legacy Aqueous Film‐Forming Foams to Japanese Quail (Coturnix japonica) Chicks
Environmental Toxicology and Chemistry ( IF 4.1 ) Pub Date : 2020-02-14 , DOI: 10.1002/etc.4684
Steven J Bursian 1, 2 , Jane E Link 1 , Michael McCarty 3 , Matt F Simcik 3
Affiliation  

As part of an effort to develop avian ecotoxicity information for poly‐ and perfluoroalkyl substances (PFAS) including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) associated with aqueous film‐forming foam (AFFF) used by the Department of Defense, the subacute toxicity of PFOS, PFOA, PFOS + PFOA, 3M AFFF, and Ansul AFFF to Japanese quail (Coturnix japonica) chicks was determined. Ten‐day‐old Japanese quail were administered treated feed for 5 d and then fed untreated feed for 18 d. Analyzed concentrations of PFOS, PFOA, and PFOS + PFOA ranged from 62 to 1955, 162 to 1208, and 43 + 45 to 296 + 292 mg kg feed–1. Analyzed concentrations of PFOS in feed containing the 3M AFFF ranged from 73 to 1399 mg kg feed–1, and formulated concentrations of 6:2 fluorotelomer thioamido sulfonate in feed containing the Ansul AFFF ranged from 9 to 1118 mg kg feed–1. Average daily doses resulting in 50% mortality at day 5 were 38 (34–43), 68 (63–74), 55 (51–59), and 130 (103–164) mg PFOS, PFOA, PFOS + PFOA, and PFOS in 3M AFFF kg body weight–1 d–1. Ansul AFFF did not result in any mortalities. Dietary concentrations resulting in 50% mortality at day 5 were 351 (275–450), 496 (427–575), 398 (339–468), and 467 (390–559) mg PFOS, PFOA, PFOS + PFOA, and PFOS in 3M AFFF kg feed–1. Environ Toxicol Chem 2021;40:695–710. © 2020 SETAC

中文翻译:

全氟辛烷磺酸和/或全氟辛酸和传统水性成膜泡沫对日本鹌鹑(Coturnix japonica)雏鸡的亚急性毒性

作为为包括全氟辛烷磺酸 (PFOS) 和全氟辛酸 (PFOA) 在内的多氟和全氟烷基物质 (PFAS) 与国防部使用的水性成膜泡沫 (AFFF) 相关联的鸟类生态毒性信息开发工作的一部分,亚急性测定了 PFOS、PFOA、PFOS + PFOA、3M AFFF 和 Ansul AFFF 对日本鹌鹑(Coturnix japonica)雏鸡的毒性。给 10 日龄日本鹌鹑喂食 5 天的处理饲料,然后喂食未经处理的饲料 18 天。PFOS、PFOA 和 PFOS + PFOA 的分析浓度范围为 62 至 1955、162 至 1208 和 43 + 45 至 296 + 292 mg kg 饲料–1。含有 3M AFFF 的饲料中 PFOS 的分析浓度范围为 73 至 1399 mg kg 饲料–1和含有 Ansul AFFF 的饲料中 6:2 氟调聚物硫代氨基磺酸盐的配制浓度范围为 9 至 1118 mg kg 饲料–1。导致第 5 天死亡率为 50% 的平均每日剂量为 38 (34–43)、68 (63–74)、55 (51–59) 和 130 (103–164) 毫克 PFOS、PFOA、PFOS + PFOA,以及3M AFFF 中的全氟辛烷磺酸 kg 体重–1  d –1。Ansul AFFF 没有造成任何死亡。导致第 5 天 50% 死亡率的膳食浓度为 351 (275–450)、496 (427–575)、398 (339–468) 和 467 (390–559) mg PFOS、PFOA、PFOS + PFOA 和 PFOS在 3M AFFF 公斤饲料–1环境毒理学化学2021;40:695-710。© 2020 SETAC
更新日期:2020-02-14
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