The introduction of clinical criteria for the operationalization of psychosis high risk provided a basis for early detection and treatment of vulnerable individuals. However, about two-thirds of people meeting clinical high-risk (CHR) criteria will never develop a psychotic disorder. In the effort to increase prognostic precision, structural and functional neuroimaging have received growing attention as a potentially useful resource in the prediction of psychotic transition in CHR patients. The present review summarizes current research on neuroimaging biomarkers in the CHR state, with a particular focus on their prognostic utility and limitations. Large, multimodal/multicenter studies are warranted to address issues important for clinical applicability such as generalizability and replicability, standardization of clinical definitions and neuroimaging methods, and consideration of contextual factors (e.g., age, comorbidity).

中文翻译：

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精神病易感性的结构和功能成像标记。

引入用于精神病高风险手术的临床标准，为早期发现和治疗弱势个体提供了基础。但是，约有三分之二的符合临床高危（CHR）标准的人永远不会患上精神病。为了提高预后的准确性，结构和功能性神经影像学已成为人们日益关注的潜在资源，可作为预测CHR患者精神病性转变的潜在有用资源。本综述总结了CHR状态下神经影像生物标记物的当前研究，特别关注其预后效用和局限性。大型，多模式/多中心研究必须解决对临床适用性重要的问题，例如泛化性和可复制性，