The prevention of type 2 diabetes mellitus (T2DM) is a target priority for the WHO and the United Nations and is a key priority in the 2018 Berlin Declaration, which is a global call for early actions related to T2DM. Health-care policies advocate that individuals at high risk of developing T2DM undertake lifestyle modification, irrespective of whether the prediabetes phenotype is defined by hyperglycaemia in the postprandial state (impaired glucose tolerance) and/or fasting state (impaired fasting glucose) or by intermediate HbA1c levels. However, current evidence indicates that diabetes prevention programmes based on lifestyle change have not been successful in preventing T2DM in individuals with isolated impaired fasting glucose. We propose that further research is needed to identify effective lifestyle interventions for individuals with isolated impaired fasting glucose. Furthermore, we call for the identification of innovative approaches that better identify people with impaired glucose tolerance, who benefit from the currently available lifestyle-based diabetes prevention programmes.

中文翻译：

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基于生活方式的T2DM预防的益处受糖尿病前期表型的影响。

预防2型糖尿病（T2DM）是WHO和联合国的目标重点，也是2018年《柏林宣言》的关键重点，《柏林宣言》是全球呼吁与T2DM相关的早期行动。卫生保健政策主张，无论是餐前状态（糖耐量受损）和/或禁食状态（空腹葡萄糖受损）还是高血糖（空腹血糖受损）还是中间HbA1c，高危人群罹患T2DM的生活方式都会改变生活方式水平。然而，目前的证据表明，基于生活方式改变的糖尿病预防计划未能成功地预防空腹血糖异常的个体中的T2DM。我们建议需要进一步的研究，以为孤立的空腹血糖受损的个体确定有效的生活方式干预措施。此外，我们呼吁确定创新方法，以更好地识别糖耐量受损的人，他们将从目前可用的基于生活方式的糖尿病预防计划中受益。