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Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels.
Acta Neuropathologica Communications ( IF 7.1 ) Pub Date : 2020-02-14 , DOI: 10.1186/s40478-020-0888-y Xuanhui Liu 1, 2 , Chuang Gao 1, 2 , Jiangyuan Yuan 1, 2 , Tangtang Xiang 1, 2 , Zhitao Gong 1, 2 , Hongliang Luo 1, 2 , Weiwei Jiang 1, 2 , Yiming Song 1, 2 , Jinhao Huang 1, 2 , Wei Quan 1, 2 , Dong Wang 1, 2 , Ye Tian 1, 2 , Xintong Ge 1, 2 , Ping Lei 3 , Jianning Zhang 1, 2 , Rongcai Jiang 1, 2
Acta Neuropathologica Communications ( IF 7.1 ) Pub Date : 2020-02-14 , DOI: 10.1186/s40478-020-0888-y Xuanhui Liu 1, 2 , Chuang Gao 1, 2 , Jiangyuan Yuan 1, 2 , Tangtang Xiang 1, 2 , Zhitao Gong 1, 2 , Hongliang Luo 1, 2 , Weiwei Jiang 1, 2 , Yiming Song 1, 2 , Jinhao Huang 1, 2 , Wei Quan 1, 2 , Dong Wang 1, 2 , Ye Tian 1, 2 , Xintong Ge 1, 2 , Ping Lei 3 , Jianning Zhang 1, 2 , Rongcai Jiang 1, 2
Affiliation
Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. The meningeal lymphatic vessel (mLV) drainage pathway is a novel system that takes part in the clearance of waste products in the central nervous system (CNS). This study aimed to explore the roles of the mLV drainage pathway in SDH clearance and its impacting factors. We injected FITC-500D, A488-fibrinogen and autologous blood into the subdural space of mice/rats and found that these substances drained into deep cervical lymph nodes (dCLNs). FITC-500D was also observed in the lymphatic vessels (LYVE+) of the meninges and the dCLNs in mice. The SDH clearance rate in SDH rats that received deep cervical lymph vessel (dCLV) ligation surgery was significantly lower than that in the control group, as evaluated by haemoglobin quantification and MRI scanning. The drainage rate of mLVs was significantly slower after the SDH model was established, and the expression of lymphangiogenesis-related proteins, including LYVE1, FOXC2 and VEGF-C, in meninges was downregulated. In summary, our findings proved that SDH was absorbed through the mLV drainage pathway and that haematomas could inhibit the function of mLVs.
中文翻译:
硬膜下血肿通过脑膜淋巴管排入颅外淋巴系统。
硬脑膜下血肿(SDH)的特征是蛛网膜和硬脑膜之间迅速或逐渐积累的血肿。到目前为止,尚未明确阐明血肿清除的机制。脑膜淋巴管(mLV)引流途径是一种新型系统,参与清除中枢神经系统(CNS)中的废物。本研究旨在探讨mLV引流途径在SDH清除中的作用及其影响因素。我们将FITC-500D,A488-纤维蛋白原和自体血注入小鼠/大鼠的硬膜下腔,发现这些物质排入了深颈淋巴结(dCLN)。在小鼠的脑膜和dCLNs的淋巴管(LYVE +)中也观察到FITC-500D。通过血红蛋白定量和MRI扫描评估,接受深颈淋巴管(dCLV)结扎手术的SDH大鼠的SDH清除率显着低于对照组。建立SDH模型后,mLVs的引流速度明显减慢,并且脑膜中淋巴管生成相关蛋白(包括LYVE1,FOXC2和VEGF-C)的表达下调。总而言之,我们的发现证明SDH通过mLV引流途径被吸收,而血肿可抑制mLVs的功能。脑膜中的FOXC2和VEGF-C被下调。总而言之,我们的发现证明SDH通过mLV引流途径被吸收,而血肿可抑制mLVs的功能。脑膜中的FOXC2和VEGF-C被下调。总而言之,我们的发现证明SDH是通过mLV引流途径吸收的,并且血肿可以抑制mLV的功能。
更新日期:2020-04-22
中文翻译:
硬膜下血肿通过脑膜淋巴管排入颅外淋巴系统。
硬脑膜下血肿(SDH)的特征是蛛网膜和硬脑膜之间迅速或逐渐积累的血肿。到目前为止,尚未明确阐明血肿清除的机制。脑膜淋巴管(mLV)引流途径是一种新型系统,参与清除中枢神经系统(CNS)中的废物。本研究旨在探讨mLV引流途径在SDH清除中的作用及其影响因素。我们将FITC-500D,A488-纤维蛋白原和自体血注入小鼠/大鼠的硬膜下腔,发现这些物质排入了深颈淋巴结(dCLN)。在小鼠的脑膜和dCLNs的淋巴管(LYVE +)中也观察到FITC-500D。通过血红蛋白定量和MRI扫描评估,接受深颈淋巴管(dCLV)结扎手术的SDH大鼠的SDH清除率显着低于对照组。建立SDH模型后,mLVs的引流速度明显减慢,并且脑膜中淋巴管生成相关蛋白(包括LYVE1,FOXC2和VEGF-C)的表达下调。总而言之,我们的发现证明SDH通过mLV引流途径被吸收,而血肿可抑制mLVs的功能。脑膜中的FOXC2和VEGF-C被下调。总而言之,我们的发现证明SDH通过mLV引流途径被吸收,而血肿可抑制mLVs的功能。脑膜中的FOXC2和VEGF-C被下调。总而言之,我们的发现证明SDH是通过mLV引流途径吸收的,并且血肿可以抑制mLV的功能。