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FAST Hydrogenations as a Continuous Platform for Green Aromatic Nitroreductions
Synlett ( IF 2 ) Pub Date : 2020-02-13 , DOI: 10.1055/s-0037-1610751
MD Taifur Rahman 1, 2 , Scott Wharry 1 , Megan Smyth 1 , Haresh Manyar 2 , Thomas S. Moody 1, 3
Affiliation  

A continuous-flow packed-bed catalytic reactor has been developed for hydrogenation of aromatic nitrobenzoic acids in water to produce the corresponding anilines. These hydrogenations are green, more efficient, less consumptive, and safer than the conventional ­reduction process. Various industrially important aromatic amines have been produced in excellent yields and with high throughput. The optimized continuous-flow reduction process produces no detectable genotoxic intermediates, unlike the corresponding batch reduction. The reactor is modular in design and can be scaled up to produce several kilograms of product per day without extensive redesign.

中文翻译:

FAST 氢化作为绿色芳香族硝基还原的连续平台

已经开发了一种连续流动填充床催化反应器,用于在水中加氢芳族硝基苯甲酸以生产相应的苯胺。与传统的还原过程相比,这些氢化反应更环保、更高效、消耗更少且更安全。各种工业上重要的芳香胺已以极好的收率和高产量生产。与相应的批量还原不同,优化的连续流还原过程不会产生可检测的基因毒性中间体。该反应器采用模块化设计,无需大量重新设计即可扩大规模,每天生产数公斤产品。
更新日期:2020-02-13
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