We performed an independent comparison of neutralizing and cross-neutralizing antibody (ab) levels seven months after initiation of three-dose, six-month vaccination schedules with the bivalent and quadrivalent human papillomavirus (HPV) vaccines in adolescent Finnish and Indian females, respectively. We used a semi-automated Pseudovirion-Based Neutralization Assay and observed significantly higher HPV16/18 peak ab-levels in bivalent as compared to quadrivalent vaccine recipients. Bivalent vaccine induced cross-neutralizing HPV31/33/45/52/58 antibodies significantly more frequently and to higher levels than the quadrivalent vaccine. The correlation of bivalent vaccine-induced HPV45 ab-levels with HPV16/18 ab-levels was stronger than that of corresponding quadrivalent vaccine-induced ab-levels, suggesting a qualitatively different cross-reactive response. Our findings on the comparison of the immunogenicity of two HPV vaccine tested in two different populations indicate that further head-to-head studies are warranted.

中文翻译：

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由二价和四价 HPV 疫苗诱导的 6/16/18/31/33/45/52/58 型人乳头瘤病毒的峰值中和和交叉中和抗体水平。

我们分别在芬兰和印度青少年女性中分别用二价和四价人乳头瘤病毒 (HPV) 疫苗接种三剂、六个月的疫苗接种计划后 7 个月对中和和交叉中和抗体 (ab) 水平进行了独立比较。我们使用了半自动化的基于假病毒的中和试验，并观察到与四价疫苗接受者相比，二价疫苗的 HPV16/18 峰值 ab 水平显着更高。与四价疫苗相比，二价疫苗诱导的交叉中和 HPV31/33/45/52/58 抗体显着更频繁且水平更高。二价疫苗诱导的HPV45 ab水平与HPV16/18 ab水平的相关性强于相应的四价疫苗诱导的ab水平，表明性质不同的交叉反应反应。我们对在两个不同人群中测试的两种 HPV 疫苗的免疫原性进行比较的结果表明，有必要进行进一步的头对头研究。