Carbon nitride materials have emerged as an efficient and sustainable class of heterogeneous photocatalysts, particularly when paired with nickel in dual catalytic cross-coupling reactions. Performing these transformations on larger scales using a continuous process is difficult due to the problems associated with handling solids in flow. By combining an oscillatory pump with a microstructured plug flow photoreactor, a stable suspension of the photocatalyst can be maintained, circumventing clogging of the reactor channels. Through careful tuning of the oscillator properties, the residence time distribution (RTD) was optimized, whilst maintaining a stable catalyst suspension. Short residence times (20 min) were achieved using optimized conditions and the recyclability of the photocatalyst was demonstrated over 10 cycles with no loss of activity. During a stable 4.5 hour scale-out demonstration, the model substrate could be isolated on 12 g scale (90% yield, 2.67 g h⁻¹). Moreover, the method was applied for the gram scale synthesis of an intermediate of the active pharmaceutical ingredient tetracaine.

中文翻译：

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振荡活塞流光反应器可促进半均相双镍/碳氮化物光催化C–N偶联

氮化碳材料已成为一种高效且可持续的多相光催化剂，特别是在双重催化交叉偶联反应中与镍配对时。由于与处理固体流有关的问题，使用连续过程在较大规模上进行这些转化是困难的。通过将振荡泵与微结构活塞流光反应器结合，可以保持光催化剂的稳定悬浮，从而避免了反应器通道的堵塞。通过仔细调整振荡器的性能，可以优化停留时间分布（RTD），同时保持稳定的催化剂悬浮液。使用优化的条件可以实现较短的停留时间（20分钟），并且在10个循环内证明了光催化剂的可回收性，且没有活性损失。^-1）。此外，该方法被用于克级合成活性药物成分丁卡因的中间体。