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Neonatal hypoglycemia after initiation of late preterm antenatal corticosteroids
Journal of Perinatology ( IF 2.9 ) Pub Date : 2020-02-14 , DOI: 10.1038/s41372-020-0589-1
Kristen R Uquillas 1 , Richard H Lee 1 , Smeeta Sardesai 2 , Ellison Chen 3 , Ugonna Ihenacho 4 , Victoria K Cortessis 4, 5 , Lorayne Barton 2
Affiliation  

Objective

To compare the frequency and severity of neonatal hypoglycemia in pregnancies treated with and without late preterm antenatal corticosteroids.

Study design

We conducted a retrospective cohort study of late preterm deliveries at LAC + USC (2015–2018). Neonatal outcomes were compared between pregnancies treated with and without corticosteroids.

Results

93 pregnancies (39.9%) received corticosteroids and 140 (60.1%) did not. Neonates born to women given corticosteroids were more likely to be hypoglycemic (47.3 vs. 29.3%, ORadj 2.25, padj = 0.01). The mean initial glucose (45.6 mg/dL vs. 51.9 mg/dL, p = 0.01) and glucose nadir (39.1 mg/dL vs. 45.4 mg/dL, p < 0.001) were significantly lower if the neonates received corticosteroids. Neonates admitted to the NICU solely for hypoglycemia were more likely to be born to women treated with corticosteroids (ORadj 4.71, padj = 0.01).

Conclusion

Administration of late preterm corticosteroids was associated with an increased incidence and severity of neonatal hypoglycemia.



中文翻译:

晚期早产产前皮质类固醇开始后的新生儿低血糖

客观的

比较使用和未使用晚期早产产前皮质类固醇治疗的妊娠中新生儿低血糖的频率和严重程度。

学习规划

我们在 LAC + USC(2015-2018 年)对晚期早产进行了回顾性队列研究。比较了使用和未使用皮质类固醇治疗的妊娠的新生儿结局。

结果

93 名孕妇 (39.9%) 接受了皮质类固醇治疗,140 名 (60.1%) 未接受。给予皮质类固醇的女性所生的新生儿更有可能出现低血糖(47.3% vs. 29.3%,OR adj 2.25,p adj  = 0.01)。 如果新生儿接受皮质类固醇,平均初始葡萄糖(45.6 mg/dL vs. 51.9 mg/dL,p  = 0.01)和葡萄糖最低点(39.1 mg/dL vs. 45.4 mg/dL,p < 0.001)显着降低。仅因低血糖而入住 NICU 的新生儿更有可能出生于接受皮质类固醇治疗的女性(OR adj 4.71,p adj  = 0.01)。

结论

晚期早产皮质类固醇的给药与新生儿低血糖的发生率和严重程度增加有关。

更新日期:2020-02-14
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