Background and Purpose- Intracranial carotid artery calcification is associated with worse outcome in anterior circulation stroke patients who undergo endovascular thrombectomy. We investigated the association between vertebrobasilar artery calcification (VBAC) and outcome in patients undergoing endovascular thrombectomy for posterior circulation large vessel occlusion. Methods- Consecutive patients treated for posterior circulation large vessel occlusion from a prospective single-center registry were studied. VBAC was manually segmented on computed tomography brain scans. The associations between VBAC and VBAC volume, functional independence (90-day modified Rankin Scale score of 0-2), and 90-day mortality were assessed using propensity score-adjusted logistic regression. Results- Sixty-four posterior circulation large vessel occlusion patients were included. Twenty-five (39.1%) patients had VBAC, and of these, the median (interquartile range) VBAC volume was 19.8 (6.65-23.4) mm3. VBAC was associated with reduced functional independence (OR, 0.19 [95% CI, 0.04-0.78]; P=0.03) and increased mortality (OR, 9.44 [95% CI, 2.43-36.62]; P=0.005). Larger VBAC volumes were a significant predictor of reduced functional independence and increased mortality. Conclusions- VBAC is an independent predictor of outcome in patients undergoing endovascular thrombectomy for posterior circulation large vessel occlusion. Considering the presence of VBAC might improve prognostication and shared treatment decision-making between patients, families, and physicians.

中文翻译：

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后循环大血管闭塞性血栓切除术的椎基底动脉钙化和结果。

背景与目的-在接受血管内血栓切除术的前循环卒中患者中，颅内颈动脉钙化与预后差有关。我们调查了椎管基底动脉钙化（VBAC）与进行后循环大血管闭塞的血管内血栓切除术患者预后之间的关联。方法-研究了从前瞻性单中心登记处接受后循环大血管闭塞治疗的连续患者。VBAC在计算机断层扫描脑部扫描中被手动分割。VBAC和VBAC量，功能独立性（90天改良Rankin量表评分为0-2）和90天死亡率之间的关联使用倾向评分调整后的逻辑回归进行了评估。结果-包括64例后循环大血管阻塞患者。25名（39.1％）患者患有VBAC，其中，VBAC体积中位数（四分位间距）为19.8（6.65-23.4）mm3。VBAC与功能独立性降低（OR，0.19 [95％CI，0.04-0.78]； P = 0.03）和死亡率增加（OR，9.44 [95％CI，2.43-36.62]； P = 0.005）相关。VBAC体积较大是功能独立性降低和死亡率增加的重要预测指标。结论-VBAC是进行后循环大血管闭塞的血管内血栓切除术患者预后的独立预测指标。考虑到VBAC的存在可能会改善患者，家属和医生之间的预后并共同制定治疗决策。VBAC体积的中位数（四分位间距）为19.8（6.65-23.4）mm3。VBAC与功能独立性降低（OR，0.19 [95％CI，0.04-0.78]； P = 0.03）和死亡率增加（OR，9.44 [95％CI，2.43-36.62]； P = 0.005）相关。VBAC体积较大是功能独立性降低和死亡率增加的重要预测指标。结论-VBAC是进行后循环大血管闭塞的血管内血栓切除术患者预后的独立预测指标。考虑到VBAC的存在可能会改善患者，家属和医生之间的预后并共同制定治疗决策。VBAC体积的中位数（四分位间距）为19.8（6.65-23.4）mm3。VBAC与功能独立性降低（OR，0.19 [95％CI，0.04-0.78]； P = 0.03）和死亡率增加（OR，9.44 [95％CI，2.43-36.62]； P = 0.005）相关。VBAC体积较大是功能独立性降低和死亡率增加的重要预测指标。结论-VBAC是进行后循环大血管闭塞的血管内血栓切除术患者预后的独立预测指标。考虑到VBAC的存在可能会改善患者，家属和医生之间的预后并共同制定治疗决策。005）。VBAC体积较大是功能独立性降低和死亡率增加的重要预测指标。结论-VBAC是进行后循环大血管闭塞的血管内血栓切除术患者预后的独立预测指标。考虑到VBAC的存在可能会改善患者，家属和医生之间的预后并共同制定治疗决策。005）。VBAC体积较大是功能独立性降低和死亡率增加的重要预测指标。结论-VBAC是进行后循环大血管闭塞的血管内血栓切除术患者预后的独立预测指标。考虑到VBAC的存在可能会改善患者，家属和医生之间的预后并共同制定治疗决策。