During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.

中文翻译：

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针对心力衰竭中与年龄相关的途径。

在衰老过程中，心脏结构和功能的恶化导致心力衰竭的易感性增加。随着老年人口的持续增长，对抗这种与年龄相关的心脏衰退的干预措施的需求变得越来越紧迫。我们对心脏老化和一般老化的理解是有限的。然而，最近对与年龄相关的衰退及其通过运动等干预措施进行预防的研究揭示了新的病理和心脏保护途径。在这篇综述中，我们总结了有关与年龄相关的心力衰竭分子机制的最新发现，并强调运动是发现这种慢性疾病急需的新型治疗靶点的宝贵实验平台。