Photosensitive carbon quantum dots (CQDs) provide a new route to treat cancer owing to their ability to produce singlet oxygen. In this paper, pH/redox/enzyme‐responsive porous silica‐based carriers with CQDs were constructed for photodynamic‐chemical combination therapy. The porous silica (pSiO₂) sample comprises uniform spheres with center‐radial channels, which is favorable for drug loading and delivery. CQDs with a size of 2.5 nm were synthesized and have the excellent ability to generate singlet oxygen. After loading CQDs and drug molecules, the channels of pSiO₂ carrier were blocked with hyaluronic acid (HA)/chitosan (CHI) layer. The disulfide bonds, conjugating HA to the surface of pSiO₂ carrier, would achieve redox‐responsive drug release, while breaking disulfide bonds and the HA/CHI layer could endow the pSiO₂ carrier enzyme/pH‐responsive drug release. The prepared pSiO₂ carriers display low cytotoxicity and good biocompatibility for multicolor imaging and photodynamic‐/chemotherapy.

中文翻译：

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制备用于光动力/化学疗法和多色细胞成像的三响应多孔二氧化硅载体和碳量子点

光敏碳量子点（CQD）由于产生单线态氧的能力而提供了治疗癌症的新途径。在本文中，构建了具有CQD的pH /氧化还原/酶反应性多孔二氧化硅基载体，用于光动力化学联合治疗。多孔二氧化硅（pSiO ₂）样品包含带有中心径向通道的均匀球体，有利于药物的装载和输送。合成了尺寸为2.5 nm的CQD，它们具有极好的产生单线态氧的能力。加载CQD和药物分子后，pSiO ₂载体的通道被透明质酸（HA）/壳聚糖（CHI）层阻塞。二硫键，将HA结合到pSiO ₂的表面载体，将实现氧化还原反应性药物释放，同时破坏二硫键，并且HA / CHI层可赋予pSiO ₂载体酶/ pH反应性药物释放。制备的pSiO ₂载体对多色成像和光动力/化学疗法显示出低细胞毒性和良好的生物相容性。