BACKGROUND Perineuriomas are rare benign peripheral nerve sheath tumours of perineurial cell origin and can be classified into intraneural and extraneural perineuriomas. They most commonly present a mononeuropathy of gradual onset and slow progression, resulting in progressive neurological deficits like hypoesthesia or motor weakness. Therapy is still variable. Aim of the study was to compare our surgical treatment and our follow-up regime including high-resolution nerve sonography with the current literature to evaluate best treatment of perineuriomas. METHODS Retrospective analysis of our dataset "peripheral nerve lesion" to identify patients suffering from perineuriomas between 01.01.2012 until 31.12.2018. Surgical treatment and the follow-up examination of three patients were described. Additionally, a systematic review including PubMed, the Cochrane Collaboration Library, Scopus and Google Scholar was performed for literature published between January 1, 1990 and October 31, 2019 independently by 2 authors. RESULTS In the first case, the left ulnar nerve was affected. In the second case, the left peroneal nerve and in the third case the right median nerve was affected. High-resolution nerve sonography was performed in each case. All patients underwent interfascicular neurolysis combined with a targeted fascicular biopsy under electrophysiological monitoring. Neurological deficits improved subsidized by rehabilitation. Surgical therapy and the neurological outcome were compared with literature. Systematic review revealed 22 articles, which met the inclusion criteria. Therefore, demographics, surgical treatment and neurological outcome of 77 patients were analysed. CONCLUSIONS Perineuriomas are rare benign nerve sheath tumours with a slow progression, sometimes difficult to diagnose. Decompression and neurolysis may improve neurological deficits. High resolution nerve sonography might serve as a helpful additional diagnostic tool in this process.

中文翻译：

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围神经瘤的现代治疗：病例系列和系统的审查。

背景技术神经鞘瘤是一种罕见的良性周围神经鞘源性神经鞘瘤，起源于神经周细胞，可分为神经内和神经外神经鞘瘤。它们最通常表现为逐渐发作和缓慢进展的单神经病，导致进行性神经功能缺损，如感觉不足或运动无力。治疗仍然是可变的。这项研究的目的是将我们的手术治疗和包括高分辨神经超声在内的随访方案与目前的文献进行比较，以评估神经鞘瘤的最佳治疗方法。方法回顾性分析我们的数据集“周围神经病变”，以识别2012年1月1日至2018年12月31日之间患有神经鞘瘤的患者。描述了三例患者的手术治疗和随访检查。另外，由2位作者分别对1990年1月1日至2019年10月31日之间发表的文献进行了系统的综述，包括PubMed，Cochrane协作库，Scopus和Google Scholar。结果在第一例中，左尺神经受到了影响。在第二种情况下，左腓神经受累，在第三种情况下，右中神经受累。在每种情况下均进行了高分辨率神经超声检查。在电生理监测下，所有患者均接受了束间神经溶解术和靶向束活检。康复补贴改善了神经功能缺损。手术治疗和神经系统的结果与文献进行了比较。系统评价显示22篇符合纳入标准的文章。因此，受众特征 分析了77例患者的手术治疗和神经系统结局。结论神经鞘瘤是一种罕见的良性神经鞘瘤，进展缓慢，有时难以诊断。减压和神经溶解可以改善神经功能缺损。高分辨率神经超声检查可能会在此过程中作为有用的附加诊断工具。