BACKGROUND Effective control of the inflammatory process in Crohn's disease (CD) is reflected in intestinal mucosal healing. The performances of faecal calprotectin (fcal), clinical and serologic parameters in the inflammatory activity evaluation and their correlation to the simple endoscopic score (SES-CD) are the goals of this study. METHODS Patients with CD referred for ileocolonoscopy were prospectively included and distributed according to the degree of endoscopic inflammatory activity into remission, mild activity, and moderate to severe activity groups. The different degrees of endoscopic activity were correlated with the following indexes: Crohn's disease activity index (CDAI), fCal, serum C-reactive protein (CRP), and haemogram. The control group comprised individuals without known intestinal disease who were referred for colorectal cancer screening. RESULTS Eighty colonoscopies were performed in patients with CD and 21 in the control group. The control group had a lower median fCal (59.7 mcg/g) than patients with CD (683 mcg/g, p < 0.001). A moderate Spearman correlation occurred between SES-CD and CRP (r = 0.525), fCal (r = 0.450), and CDAI (r = 0.407), while a weak correlation was found with the platelet count (r = 0.257). Only fCal distinguished patients in remission from those with mild activity (236.6 mcg/g × 654.9 mcg/g, p = 0.014) or moderate to severe activity (236.6 mcg/g × 1128 mcg/g, p < 0.001). An fCal cut-off of 155 mcg/g was sensitive (96%) and accurate (78%) for the diagnosis of endoscopic activity. CONCLUSIONS fCal provides greater diagnostic accuracy than the other activity markers for endoscopic activity of patients with CD, moderate correlation to SES-CD, and a capacity to discriminate patients in remission from those with mild or moderate to severe activity.

中文翻译：

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粪便钙卫蛋白是在克罗恩病中最能区分缓解与内镜活动程度不同的生物标志物。

背景技术在肠粘膜愈合中反映了对克罗恩病（CD）中炎症过程的有效控制。粪便钙卫蛋白（fcal）的性能，炎性活性评估中的临床和血清学参数及其与简单内镜评分（SES-CD）的相关性是本研究的目标。方法前瞻性纳入接受回肠结肠镜检查的CD患者，并根据内镜下炎症活动的程度分为缓解，轻度活动和中度至重度活动组。内窥镜活动度的不同程度与以下指标相关：克罗恩病活动指数（CDAI），fCal，血清C反应蛋白（CRP）和血流图。对照组包括没有已知肠道疾病的个体，将其转诊接受大肠癌筛查。结果CD患者进行80例结肠镜检查，对照组21例。对照组的中位数fCal（59.7 mcg / g）低于CD患者（683 mcg / g，p <0.001）。SES-CD和CRP（r = 0.525），fCal（r = 0.450）和CDAI（r = 0.407）之间出现中等Spearman相关性，而与血小板计数之间存在弱相关性（r = 0.257）。只有fCal可以将轻度活动（236.6 mcg / g×654.9 mcg / g，p = 0.014）或中度至重度活动（236.6 mcg / g×1128 mcg / g，p <0.001）的患者区分开。fCal临界值为155 mcg / g，对于内镜活动的诊断是敏感的（96％）和准确的（78％）。