Abstract

Microfluidic technologies are reliable methods to obtain uniform and tiny droplets, but their application is limited by the capacity of single microchannel and the difficulty in fabrication and operation of large amounts of parallel droplet generators. Here, we reported a microchannel device equipped with multiple capillaries for rupturing the dispersed fluid, which realized droplet generation frequency up to 40 kHz in a single microchannel. The microchannel was operated under jetting flow, which was robust for controlling the droplet size uniformity; therefore, the device did not need highly precise machinery and accurate installation during fabrication. 30–100 μm droplets with CV <5% were successfully prepared in a 20-capillary embedded microchannel device with high throughput, verifying the effectiveness of improving the working ability of micro-channel unit in the scale-up of microfluidic device.

中文翻译：

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高通量制备在多个毛细管中逐步嵌入微通道的均匀细小液滴

摘要

微流体技术是获得均匀且微小的液滴的可靠方法，但是其应用受到单个微通道的容量以及制造和操作大量平行液滴发生器的困难的限制。在这里，我们报道了一种微通道设备，该设备配备了多个用于破裂分散流体的毛细管，在单个微通道中实现了高达40 kHz的液滴产生频率。该微通道在喷射流下操作，对于控制液滴尺寸的均匀性是稳定的。因此，该设备在制造过程中不需要高精度的机械和精确的安装。在具有20个毛细管的嵌入式微通道设备中以高通量成功制备了CV <5％的30–100μm液滴，