当前位置: X-MOL 学术Environ. Sci. Pollut. Res. › 论文详情
Nephroprotective effects of curcumin loaded chitosan nanoparticles in cypermethrin induced renal toxicity in rabbits
Environmental Science and Pollution Research ( IF 2.914 ) Pub Date : 2020-02-13 , DOI: 10.1007/s11356-020-08051-5
Maira Anwar, Faqir Muhammad, Bushra Akhtar, Sajjad ur Rehman, Muhammad Kashif Saleemi

Abstract Cypermethrin, a pyrethroid insecticide, may cause several adverse effects including nephrotoxicity. Curcumin is a nutraceutical with many pharmacological effects including nephroprotective effects. But its effective clinical use is limited due to poor bioavailability, physicochemical instability, low bioactive absorption, quick metabolization, less penetration, and targeting efficacy. To resolve these issues, curcumin is incorporated in chitosan nanoparticles. The focus of the study was to prepare and characterize curcumin loaded chitosan nanoparticles and evaluate their nephroprotective activity in a cypermethrin induced renal toxicity. The curcumin loaded chitosan nanoparticles were prepared by using solvent displacement method and characterized by particle size, zeta potential, polydispersity index, entrapment efficiency, and FTIR. The prepared formulation was stable and lies within nanometer range (264.8 nm), and possessed high drug loading capacity (84.64%). Cypermethrin (24 mg/kg body weight) and Curcumin loaded chitosan nanoparticles (15 mg/kg and 30 mg/kg body weight) were orally administered to 20 rabbits (4 groups) for 28 days. It was found that cypermethrin significantly increased the serum levels of creatinine, urea, and BUN and decreased glutathione S-transferase and superoxide dismutase. Co-administration of curcumin loaded chitosan nanoparticles provided pronounced beneficial effects against cypermethrin-induced biochemical alterations and oxidative damage in the kidneys of rabbits. 30 mg/kg body weight of curcumin loaded chitosan nanoparticles have better nephroprotective effects as compared to 15 mg/kg body weight.
更新日期:2020-02-13

 

全部期刊列表>>
Springer Nature 2019高下载量文章和章节
化学/材料学中国作者研究精选
《科学报告》最新环境科学研究
ACS材料视界
自然科研论文编辑服务
中南大学国家杰青杨华明
剑桥大学-
中国科学院大学化学科学学院
材料化学和生物传感方向博士后招聘
课题组网站
X-MOL
北京大学分子工程苏南研究院
华东师范大学分子机器及功能材料
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug