BACKGROUND Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma using radiofrequency energy to target airway remodeling including smooth muscle. The correlation of pulmonary function tests and BT response are largely unknown. Forced Oscillation Technique (FOT) is an effort-independent technique to assess respiratory resistance (Rrs) by using pressure oscillations including small airways. AIM To investigate the effect of BT on pulmonary function, assessed by spirometry, bodyplethysmography and FOT and explore associations between pulmonary function parameters and BT treatment response. METHODS Severe asthma patients recruited to the TASMA trial were analyzed in this observational cohort study. Spirometry, bodyplethysmography and FOT measurements were performed before and 6 months after BT. Asthma questionnaires (AQLQ/ACQ-6) were used to assess treatment response. RESULTS Twenty-four patients were analyzed. AQLQ and ACQ improved significantly 6 months after BT (AQLQ 4.15 (±0.96) to 4.90 (±1.14) and ACQ 2.64 (±0.60) to 2.11 (±1.04), p = 0.004 and p = 0.02 respectively). Pulmonary function parameters remained stable. Improvement in FEV1 correlated with AQLQ change (r = 0.45 p = 0.03). Lower respiratory resistance (Rrs) at baseline (both 5 Hz and 19 Hz) significantly correlated to AQLQ improvement (r = - 0.52 and r = - 0.53 respectively, p = 0.01 (both)). Borderline significant correlations with ACQ improvement were found (r = 0.30 p = 0.16 for 5 Hz and r = 0.41 p = 0.05 for 19 Hz). CONCLUSION Pulmonary function remained stable after BT. Improvement in FEV1 correlated with asthma questionnaires improvement including AQLQ. Lower FOT-measured respiratory resistance at baseline was associated with favorable BT response, which might reflect targeting of larger airways with BT. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT02225392; Registered 26 August 2014.

中文翻译：

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用强制振荡技术（FOT）测量的呼吸系统阻力与支气管热成形反应有关。

背景技术支气管热成形术（BT）是一种使用射频能量靶向气道重塑（包括平滑肌）的严重哮喘的内镜治疗方法。肺功能测试和BT反应之间的相关性很大程度上未知。强迫振荡技术（FOT）是一种与精力无关的技术，可通过使用包括小气道在内的压力振荡来评估呼吸阻力（Rrs）。目的通过肺活量测定，人体体积描记法和FOT评估BT对肺功能的影响，并探讨肺功能参数与BT治疗反应之间的关系。方法在这项观察性队列研究中分析了招募至TASMA试验的严重哮喘患者。在BT之前和之后6个月进行肺活量测定，人体体积描记和FOT测量。哮喘问卷（AQLQ / ACQ-6）用于评估治疗反应。结果分析了24例患者。BT后6个月，AQLQ和ACQ显着改善（AQLQ 4.15（±0.96）至4.90（±1.14）和ACQ 2.64（±0.60）至2.11（±1.04），分别为p = 0.004和p = 0.02）。肺功能参数保持稳定。FEV1的改善与AQLQ的变化相关（r = 0.45 p = 0.03）。基线时的较低呼吸阻力（Rrs）（5 Hz和19 Hz）与AQLQ改善显着相关（r =-0.52和r =-0.53，p = 0.01（均为p））。发现与ACQ改善之间的临界显着相关性（5 Hz时r = 0.30 p = 0.16，而19 Hz时r = 0.41 p = 0.05）。结论BT后肺功能保持稳定。FEV1的改善与哮喘问卷（包括AQLQ）的改善相关。基线时FOT测量的较低呼吸阻力与良好的BT反应相关，这可能反映了以BT为较大气道的目标。试验注册ClinicalTrials.gov标识符：NCT02225392; 2014年8月26日注册。