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Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells.
BMC Complementary and Alternative Medicine ( IF 4.782 ) Pub Date : 2020-02-11 , DOI: 10.1186/s12906-020-2838-4 Chao Tong 1, 2 , Zewen Chen 1 , Fang Liu 1 , Yanyan Qiao 1 , Tong Chen 1 , Xuebing Wang 1, 3
BMC Complementary and Alternative Medicine ( IF 4.782 ) Pub Date : 2020-02-11 , DOI: 10.1186/s12906-020-2838-4 Chao Tong 1, 2 , Zewen Chen 1 , Fang Liu 1 , Yanyan Qiao 1 , Tong Chen 1 , Xuebing Wang 1, 3
Affiliation
BACKGROUND
Radix isatidis has been used in China and other Asian countries for its antiviral and anti-inflammatory effects for thousands of years. However, the antiviral effect of Radix isatidis polysaccharide against pseudorabies virus (PRV) is still unknown.
METHODS
The polysaccharide were isolated from extract of the roots of Radix isatidis. MTT assays were used to determine the preventive effect, inhibitory effect and antiviral effect of Radix isatidis polysaccharide on PRV in vitro.
RESULTS
This study found that different concentrations of polysaccharides from this plant can inhibit PRV replication by 14.674-30.840%, prevent infection at rates of 6.668-14.923%, and kill this virus at rates of 32.214-67.422%.
CONCLUSION
These results broaden the understanding of this traditional Chinese herb and provide a theoretical basis for further research. Moreover, Radix isatidis polysaccharide could be used for antiviral therapy.
更新日期:2020-03-22