Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (ILCs) have been considered crucial in maintaining tissue homeostasis and bridges between innate and adaptive immune system. Altered ILCs' subset distribution and function have been observed in a variety of autoimmune and chronic inflammatory diseases and suggest a subset-specific role of ILCs in the pathogenesis of immune-mediated inflammation. In this review, we focus on the current knowledge of ILC subset and their role in inflammatory arthritis, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), enteropathic arthritis, and other seronegative spondyloarthritis. By better understanding the biology and function of ILC subset in different disease settings, new therapeutic interventions can be anticipated by modulating dysregulated ILC responses toward promoting resolution of inflammation.

中文翻译：

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炎性关节炎中的先天淋巴样细胞。

免疫系统的异常激活和失调是许多形式的炎症性关节炎的共同特征。自从它们被鉴定为白细胞的独特种群以来，先天性淋巴样细胞（ILC）被认为在维持组织稳态以及先天性和适应性免疫系统之间的桥梁方面至关重要。在多种自身免疫性疾病和慢性炎症性疾病中，ILC的亚群分布和功能发生了变化，提示ILC在免疫介导的炎症发病机制中具有亚群特异性作用。在这篇综述中，我们关注于ILC亚群及其在炎症性关节炎中的作用的当前知识，包括类风湿性关节炎（RA），强直性脊柱炎（AS），银屑病关节炎（PsA），肠病性关节炎和其他血清阴性的脊柱关节炎。