There are great challenges to fabricate a highly selective and sensitive enzyme‐free biomimetic sensor. Herein for the first time a unique nanostructure of porous molybdenum carbide impregnated in N‐doped carbon (p‐Mo₂C/NC) is synthesized by using SiO₂ nanocrystals‐templating method and is further used as an enzyme‐free electrochemical biosensor toward highly selective, sensitive detection of H₂O₂, of which the limit of detection, dynamic detection range and sensitivity accomplish as 0.22 μM, 0.05–4.5 mM and 577.14 μA mM⁻¹ cm⁻², respectively, and are much superior to the non‐porous molybdenum carbide impregnated in N‐doped carbon (Mo₂C/NC). The sensor is also used to monitor H₂O₂ released from A549 living cells. This work holds a great promise to be used to monitor the presence of H₂O₂ in biological research while offering an important knowledge to design a highly selective and sensitive biomimetic sensor by synthesizing a porous catalyst to greatly improve the reaction surface area rather than conventionally only relying on dispersing the catalyst material into porous carbon substrate.

中文翻译：

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多孔碳化钼纳米结构催化剂对H2O2的高仿生感测

制造高度选择性和灵敏的无酶仿生传感器面临着巨大的挑战。本文首次通过SiO ₂纳米晶体模板化方法合成了一种掺入N掺杂碳（p-Mo ₂ C / NC）中的多孔碳化钼的独特纳米结构，并进一步用作无酶电化学生物传感器H ₂ O _2的选择性，灵敏检测，其检测限，动态检测范围和灵敏度分别达到0.22μM，0.05-4.5 mM和577.14μAmM ^-1  cm ^-2，并且比非氮掺杂碳中浸渍的多孔碳化钼（Mo ₂C / NC）。该传感器还用于监测从A549活细胞释放的H ₂ O ₂。这项工作具有广阔的前景，可用于监测生物学研究中H ₂ O ₂的存在，同时提供重要的知识，可通过合成多孔催化剂大大提高反应表面积，从而设计出高度选择性和灵敏的仿生传感器。仅依靠将催化剂材料分散到多孔碳基质中。