We read the manuscript written by Suzuki et al 1 with interest. They reported that the eradication rate of Helicobacter pylori attained by the dual therapy with vonoprazan and amoxicillin (VA-Dual) was almost the same as that attained by the triple therapy with vonoprazan, amoxicillin and clarithromycin (VAC-Triple), as previously reported by us.2 The most interesting point in this paper was that the VA-Dual therapy was superior to the VAC-Triple therapy in eradicating the clarithromycin-resistant strains of H. pylori . In this regard, the authors consider the possibilities of a type I error, the difference in the proportion of amoxicillin-resistant strains, and the excessive inhibition of gastric acid secretion …

中文翻译：

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克拉霉素对克拉霉素耐药幽门螺杆菌感染患者阿莫西林杀菌效果的影响

我们饶有兴趣地阅读了 Suzuki 等人 1 撰写的手稿。他们报告说，沃诺拉赞和阿莫西林双联疗法（VA-Dual）的幽门螺杆菌根除率与沃诺拉赞、阿莫西林和克拉霉素三联疗法（VAC-Triple）的根除率几乎相同，正如之前报道的那样us.2 本文最有趣的一点是，VA-Dual 疗法在根除对克拉霉素耐药的幽门螺杆菌菌株方面优于 VAC-Triple 疗法。对此，作者考虑了I型错误的可能性，阿莫西林耐药菌株比例的差异，以及胃酸分泌过度抑制……