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Quantitative attenuation accuracy of virtual non-enhanced imaging compared to that of true non-enhanced imaging on dual-source dual-energy CT.
Abdominal Radiology ( IF 2.4 ) Pub Date : 2020-04-01 , DOI: 10.1007/s00261-020-02415-8
Sanaz Javadi 1 , Sherif Elsherif 2 , Priya Bhosale 1 , Corey T Jensen 1 , Rick R Layman 3 , Megan C Jacobsen 3 , Ott Le 1 , Sun Jia 4 , Rajan J Parikh 5 , Eric P Tamm 1
Affiliation  

PURPOSE To evaluate the quantitative attenuation and reliability of virtual non-contrast (VNC) images of the abdomen acquired from multiphasic scans with a dual-energy computed tomography (DECT) system and compare it with that of true non-enhanced images (TNC) on second- (Flash) and third- (Force) generation DECT scanners. METHODS This retrospective study was approved by the institutional review board and included 123 patients with pancreatic cancer who had undergone routine clinical multiphasic DECT examinations at our institution using Flash and Force scanners between March and August 2017. VNC images of the abdomen were reconstructed from late arterial phase images. For every patient, regions-of-interest were defined in the aorta, fluid-containing structures (gallbladder, pleural effusion, and renal cysts > 10 mm), paravertebral muscles, subcutaneous fat, spleen, pancreas, renal cortex, and liver (eight locations) on TNC and VNC images. The mean attenuation of VNC was compared with TNC by organ for each CT scanner using an equivalence test and the Bland-Altman plot. The mean attenuations for TNC or VNC were compared between the Force and Flash CT scanners using a two-sample t test. RESULTS The VNC attenuation of organs on the Force scanner was lower than was that on the Flash, and the mean attenuation difference in different organs on the Force was closer to 0. The estimated means of TNC and VNC were equivalent for an equivalence margin of 10 on the Force scanner. CONCLUSION VNC images in DECT are a promising alternative to TNC images. In clinical scenarios in which non-enhanced CT images are required but are not available for accurate diagnosis, VNC images can potentially serve as an alternative to TNC images without the radiation exposure risks.

中文翻译:

与双源双能CT上的真实非增强成像相比,虚拟非增强成像的定量衰减精度。

目的评估使用双能计算机断层扫描(DECT)系统从多相扫描获取的腹部虚拟非对比度(VNC)图像的定量衰减和可靠性,并将其与真实的非增强图像(TNC)进行比较第二代(Flash)和第三代(强制)DECT扫描仪。方法这项回顾性研究获得了机构审查委员会的批准,纳入了123例胰腺癌患者,这些患者在2017年3月至2017年8月期间使用Flash和Force扫描仪在我们机构接受了常规的临床多相DECT检查。腹部的VNC图像是根据晚期动脉重建的相位图像。对于每个患者,在主动脉,含液体的结构(胆囊,胸腔积液和肾囊肿> 10 mm),椎旁肌,TNC和VNC图像上的皮下脂肪,脾脏,胰腺,肾皮质和肝脏(八个位置)。使用等效测试和Bland-Altman图,通过每台CT扫描器的器官比较VNC的平均衰减与TNC。使用两次样本t检验比较了Force和Flash CT扫描仪对TNC或VNC的平均衰减。结果Force扫描仪上器官的VNC衰减比Flash上​​的低,并且Force上不同器官的平均衰减差接近于0。TNC和VNC的估计均值在10的等效范围内是等效的在Force扫描仪上。结论DECT中的VNC图像可以替代TNC图像。在需要非增强CT图像但无法进行准确诊断的临床情况下,
更新日期:2020-02-12
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