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Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
Science Translational Medicine ( IF 17.161 ) Pub Date : 2020-02-12 , DOI: 10.1126/scitranslmed.aax6337
Jesse M. Jaynes, Rushikesh Sable, Michael Ronzetti, Wendy Bautista, Zachary Knotts, Abisola Abisoye-Ogunniyan, Dandan Li, Raul Calvo, Myagmarjav Dashnyam, Anju Singh, Theresa Guerin, Jason White, Sarangan Ravichandran, Parimal Kumar, Keyur Talsania, Vicky Chen, Anghesom Ghebremedhin, Balasubramanyam Karanam, Ahmad Bin Salam, Ruksana Amin, Taivan Odzorig, Taylor Aiken, Victoria Nguyen, Yansong Bian, Jelani C. Zarif, Amber E. de Groot, Monika Mehta, Lixin Fan, Xin Hu, Anton Simeonov, Nathan Pate, Mones Abu-Asab, Marc Ferrer, Noel Southall, Chan-Young Ock, Yongmei Zhao, Henry Lopez, Serguei Kozlov, Natalia de Val, Clayton C. Yates, Bolormaa Baljinnyam, Juan Marugan, Udo Rudloff

Solid tumors elicit a detectable immune response including the infiltration of tumor-associated macrophages (TAMs). Unfortunately, this immune response is co-opted into contributing toward tumor growth instead of preventing its progression. We seek to reestablish an antitumor immune response by selectively targeting surface receptors and endogenous signaling processes of the macrophage subtypes driving cancer progression. RP-182 is a synthetic 10-mer amphipathic analog of host defense peptides that selectively induces a conformational switch of the mannose receptor CD206 expressed on TAMs displaying an M2-like phenotype. RP-182–mediated activation of this receptor in human and murine M2-like macrophages elicits a program of endocytosis, phagosome-lysosome formation, and autophagy and reprograms M2-like TAMs to an antitumor M1-like phenotype. In syngeneic and autochthonous murine cancer models, RP-182 suppressed tumor growth, extended survival, and was an effective combination partner with chemo- or immune checkpoint therapy. Antitumor activity of RP-182 was also observed in CD206high patient-derived xenotransplantation models. Mechanistically, via selective reduction of immunosuppressive M2-like TAMs, RP-182 improved adaptive and innate antitumor immune responses, including increased cancer cell phagocytosis by reprogrammed TAMs.
更新日期:2020-02-12

 

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