Cu/(Ph-pybox)-catalyzed asymmetric dearomative alkynylation of isoquinolines has been realized in high to excellent enantioselectivities (up to 96% ee) with α-bromoacetophenone as an activator and 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate as an additive. This novel reaction tolerates a wide variety of functional groups and affords enantioenriched C1-alkynyl 1,2-dihydroisoquinolines in high yields and ee under mild conditions.

中文翻译：

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铜催化异喹啉的不对称脱芳香烷基化

以α-溴苯乙酮为激活剂和1,1'-联萘-2,2'-二基的Cu /（Ph-pybox）催化的异喹啉的不对称脱芳香性炔基化反应具有很高至优异的对映选择性（至96％ee）磷酸氢盐作为添加剂。这种新颖的反应可耐受各种官能团，并在温和条件下以高收率和ee提供对映体富集的C1-炔基1,2-二氢异喹啉。