Faithful chromosome segregation during mitosis in eukaryotes requires attachment of the kinetochore, a large protein complex assembled on the centromere of each chromosome, to the spindle microtubules. The kinetochore is a structural interface for the microtubule attachment and provides molecular surveillance mechanisms that monitor and ensure the precise microtubule attachment as well, including error correction and spindle assembly checkpoint. During mitotic progression, the kinetochore undergoes dynamic morphological changes that are observable through electron microscopy as well as through fluorescence microscopy. These structural changes might be associated with the kinetochore function. In this review, we summarize how the dynamics of kinetochore morphology are associated with its functions and discuss recent findings on the switching of protein interaction networks in the kinetochore during cell cycle progression.

真核生物在有丝分裂过程中忠实的染色体分离需要将线粒体（纺锤体，一种在每个染色体的着丝粒上组装的大蛋白复合体）附着到纺锤体微管上。动粒是微管附着的结构接口，并提供了分子监视机制来监视并确保精确的微管附着，包括错误校正和主轴组件检查点。在有丝分裂过程中，线粒体经历了动态形态学变化，这种变化可以通过电子显微镜以及荧光显微镜观察到。这些结构变化可能与动线功能有关。在这篇评论中