Subjective well-being (SWB), depressive symptoms, and neuroticism are common and vital traits of mental disorders. Genetic mechanisms of SWB, depressive symptoms and neuroticism remain elusive now. The large-scale GWAS summary datasets of SWB (n = 229,883), depressive symptoms (n = 180,866), and neuroticism (n = 170,911) were obtained from published studies. MASH tool was applied to the GWAS datasets for identifying candidate SNPs shared by SWB, depressive symptoms and neuroticism. SNPs detected by MASH, were then mapped to target genes considering regulatory SNP (rSNP), methylated quantitative trait locus (MeQTL) and the SNPs near to known genes. Gene set enrichment analysis (GSEA) was conducted by the FUMA platform. A total of 122 candidate SNPs were detected by MASH analysis, mapping to 29 target genes, such as CLDN23, MSRA and XKR6. GO enrichment analysis identified multiple immune related gene sets for SWB, depressive symptoms and neuroticism, such as GSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_48H_DN (P = 7.32 × 10-3), GSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD4_TCELL_DN (P = 2.52 × 10-2). We also found some mental disorders related gene sets were associated with three phenotypes, such as mood instability (P = 1.15 × 10-6) and neuroticism (P = 1.72 × 10-6). We identified multiple candidate genes and GO terms shared by SWB, depressive symptoms and neuroticism. Our results support the overlapping genetic mechanisms, and suggest a functional correlation between immunity and SWB, depressive symptoms and neuroticism.

中文翻译：

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全基因组多表型关联分析确定了主观幸福感，抑郁症状和神经质病的常见候选基因。

主观幸福感（SWB），抑郁症状和神经质病是精神障碍的常见和重要特征。SWB，抑郁症状和神经质的遗传机制目前仍不清楚。SWB的大规模GWAS摘要数据集（n = 229,883），抑郁症状（n = 180,866）和神经质（n = 170,911）是从已发表的研究中获得的。MASH工具应用于GWAS数据集，以识别SWB共享的候选SNP，抑郁症状和神经质。然后，通过调节性SNP（rSNP），甲基化数量性状基因座（MeQTL）和已知基因附近的SNP，将MASH检测到的SNP定位到目标基因。基因组富集分析（GSEA）由FUMA平台进行。通过MASH分析检测到总共122个候选SNP，定位到29个靶基因，例如CLDN23，MSRA和XKR6。GO富集分析确定了针对SWB，抑郁症状和神经质的多种免疫相关基因集，例如GSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_48H_DN（P = 7.32×10-3），GSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD4_TC2_2.5（10 = 2）。我们还发现一些与精神疾病相关的基因集与三种表型有关，例如情绪不稳定（P = 1.15×10-6）和神经质（P = 1.72×10-6）。我们确定了SWB，抑郁症状和神经质共有的多个候选基因和GO术语。我们的结果支持重叠的遗传机制，并表明免疫力与SWB，抑郁症状和神经质之间存在功能相关性。例如GSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_48H_DN（P = 7.32×10-3），GSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD4_TCELL_DN（P = 2.52×10-2）。我们还发现一些与精神疾病相关的基因集与三种表型有关，例如情绪不稳定（P = 1.15×10-6）和神经质（P = 1.72×10-6）。我们确定了SWB，抑郁症状和神经质共有的多个候选基因和GO术语。我们的结果支持重叠的遗传机制，并表明免疫力与SWB，抑郁症状和神经质之间存在功能相关性。例如GSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_48H_DN（P = 7.32×10-3），GSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD4_TCELL_DN（P = 2.52×10-2）。我们还发现一些与精神疾病相关的基因集与三种表型有关，例如情绪不稳定（P = 1.15×10-6）和神经质（P = 1.72×10-6）。我们发现了SWB，抑郁症状和神经质共有的多个候选基因和GO术语。我们的结果支持重叠的遗传机制，并表明免疫力与SWB，抑郁症状和神经质之间存在功能相关性。我们发现了SWB，抑郁症状和神经质共有的多个候选基因和GO术语。我们的结果支持重叠的遗传机制，并表明免疫力与SWB，抑郁症状和神经质之间存在功能相关性。我们确定了SWB，抑郁症状和神经质共有的多个候选基因和GO术语。我们的结果支持重叠的遗传机制，并表明免疫力与SWB，抑郁症状和神经质之间存在功能相关性。