Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

中文翻译：

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阐明硫代硫酸盐硫转移酶在代谢疾病中的作用。

硫代硫酸盐硫转移酶（TST，EC 2.8.1.1），也称为罗丹尼斯语，是一种线粒体酶，可催化硫在多种分子途径中的转移。在最初被鉴定为氰化物解毒酶之后，发现其功能还包括硫代谢，铁硫簇的修饰以及抗氧化剂谷胱甘肽和硫氧还蛋白的还原。TST缺乏症与包括糖尿病和肥胖症在内的新陈代谢疾病的病理生理密切相关。这篇综述总结了与TST的酶学性质和功能有关的研究，然后探讨了TST对线粒体的影响与糖尿病和肥胖症等疾病发展之间的关系。