To keep autoreactive T cells under control in SLE patients, immunosuppressive regimens are used, which can increase susceptibility to bacterial and viral infections. Recently, Katsuyama et al., demonstrated that the CD38/NAD/Sirtuin1/EZH2 axis reduces cytolytic CD8+ T cell function and might be targeted to overcome incidence of infections.

中文翻译：

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CD38：调节SLE中的组蛋白甲基转移酶EZH2活性。

为了使SLE患者的自身反应性T细胞得到控制，使用了免疫抑制方案，可以增加对细菌和病毒感染的敏感性。最近，Katsuyama等人证明，CD38 / NAD / Sirtuin1 / EZH2轴可降低细胞溶解性CD8 + T细胞的功能，并有可能克服感染的发生。