Endurance exercise training promotes numerous biochemical adaptations within skeletal muscle fibers culminating into a phenotype that is safeguarded against numerous perils including doxorubicin-induced myopathy and inactivity-induced muscle atrophy. This exercise-induced protection of skeletal muscle fibers is commonly termed “exercise preconditioning”. This review will discuss the biochemical mechanisms responsible for exercise-induced protection of skeletal muscle fibers against these harmful events. The first segment of this report highlights the evidence that endurance exercise training provides cytoprotection to skeletal muscle fibers against several potentially damaging insults. The second and third sections of the review will discuss the cellular adaptations responsible for exercise-induced protection of skeletal muscle fibers against doxorubicin-provoked damage and inactivity-induced fiber atrophy, respectively. Importantly, we also identify gaps in our understanding of exercise preconditioning in hopes of stimulating future research.

耐力运动训练可促进骨骼肌纤维内的多种生化适应，最终形成一种表型，可以抵抗许多危险，包括阿霉素引起的肌病和非活动性引起的肌肉萎缩。这种运动诱导的骨骼肌纤维保护通常被称为“运动预适应”。这篇综述将讨论负责运动诱导的骨骼肌纤维抵抗这些有害事件的生化机制。本报告的第一部分重点介绍了耐力运动训练可为骨骼肌纤维提供细胞保护作用的证据，以抵御几种潜在的破坏性伤害。综述的第二部分和第三部分将分别讨论负责适应运动诱导的骨骼肌纤维抵抗阿霉素引起的损伤和不活动引起的纤维萎缩的细胞适应。重要的是，我们还确定了我们对运动预处理的理解方面的差距，以期刺激未来的研究。