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Carbon dots as versatile nanoarchitectures for the treatment of neurological disorders and their theranostic applications: A review.
Advances in Colloid and Interface Science ( IF 15.6 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.cis.2020.102123
Milad Ashrafizadeh 1 , Reza Mohammadinejad 2 , Suresh Kumar Kailasa 3 , Zahra Ahmadi 4 , Elham Ghasemipour Afshar 5 , Abbas Pardakhty 2
Affiliation  

The development of novel methods plays a fundamental role in early diagnosis and controlling of neurological disorders (NDs). Blood-brain barrier (BBB) is the most challenging barrier for the development of neuro drug delivery systems due to its inhibiting ability to enter drugs and agents into central nervous system (CNS). Carbon dots (CDs) have shown to be very promising and outstanding agents for various biomedical applications (bio imaging studies, treatment of NDs and brain tumors). They exhibit remarkable properties such as biocompatibility, small size (less than 10 nm, enabling penetration into BBB), tunable optical properties, photostability and simple synthetic procedures, allowing them to act as ideal candidates in various fields of science. Therefore, the objective of this review is to overview the recent studies on CDs for the development of neuro drug delivery systems to reach CNS via crossing of BBB. Primarily, this review briefly outlines the unique optical properties and toxicity of CDs. The development of novel neuro drug delivery systems for various neurological disorders using CDs as carriers is described. This review also covers the potential applications of CDs in brain tumors imaging and treatment of neurodegenerative diseases. Finally, the sensing applications and future prospects of CDs are summarized.

中文翻译:

碳点作为用于治疗神经系统疾病及其治疗学应用的多功能纳米结构:综述。

新方法的开发在神经系统疾病(NDs)的早期诊断和控制中起着基本作用。血脑屏障(BBB)由于其抑制药物和药剂进入中枢神经系统(CNS)的能力而成为神经药物输送系统发展中最具挑战性的屏障。碳点(CD)已被证明是用于各种生物医学应用(生物成像研究,ND和脑瘤治疗)的非常有前途和杰出的药物。它们表现出非凡的特性,例如生物相容性,小尺寸(小于10 nm,可渗透到BBB中),可调节的光学特性,光稳定性和简单的合成程序,使它们成为各种科学领域的理想候选者。因此,这篇综述的目的是概述有关CD的最新研究,该CD用于开发通过BBB穿越到达CNS的神经药物递送系统。首先,本文简要概述了CD的独特光学性质和毒性。描述了使用CD作为载体的用于各种神经系统疾病的新型神经药物递送系统的开发。这篇综述还涵盖了CD在脑肿瘤成像和神经退行性疾病治疗中的潜在应用。最后,总结了CD的传感应用和未来前景。这篇综述还涵盖了CD在脑肿瘤成像和神经退行性疾病治疗中的潜在应用。最后,总结了CD的传感应用和未来前景。这篇综述还涵盖了CD在脑肿瘤成像和神经退行性疾病治疗中的潜在应用。最后,总结了CD的传感应用和未来前景。
更新日期:2020-02-12
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