In a cross-sectional study of individuals with type 1 diabetes mellitus, those who were designated to be slow disease progressors had an increased proportion of autoreactive, islet-specific CD8+ T cells expressing an ‘exhausted’ phenotype. By contrast, rapid disease progressors had increased numbers of islet-specific CD8+ T cells with a transitional memory phenotype.

中文翻译：

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T1DM 进展的预测性 CD8+ T 细胞表型。

在一项针对 1 型糖尿病患者的横断面研究中，那些被指定为疾病进展缓慢者的自身反应性、胰岛特异性 CD8+ T 细胞表达“衰竭”表型的比例增加。相比之下，快速疾病进展者具有过渡记忆表型的胰岛特异性 CD8+ T 细胞数量增加。