Impact of isolation precautions on psychological wellbeing of patients has yet to be fully quantified. To assess the impact of isolation precautions on patients' health-related quality of life and depression or anxiety scales and estimate per day cost of anxiety and depression. Literature pertaining to impact of isolation precautions was searched on EMBASE and PubMed databases and Google Scholar. A two-step independent screening of the articles was performed. Articles that compared isolated and non-isolated patients using different quality of life and psychological burden scales were included. A meta-analysis was conducted using the Hospital Anxiety and Depression Scales (HADS-A and HADS-D). Psychological burden measures from selected literature were presented in a graph as effect sizes. Per day cost of anxiety and depression was estimated using pooled mean difference from meta-analysis. Out of 106 articles, 94 were excluded due to inclusion criteria, leaving 12 for full text review. After review of full text of the articles, seven articles were shortlisted for empirical analysis and four out of these seven for meta-analysis. The pooled mean difference estimates for HADS-A was -1.4 (P=0.15) and that for HADS-D was -1.85 (P=0.09). In the empirical analysis of psychological burden scales, the effect in all studies except one was negative. Results from meta-analysis and empirical analysis of psychological burden implied that isolated patients are worse off in general. The implied estimated per day cost of anxiety and depression in terms of quality-adjusted life years (QALYs) is approximately US$10.

中文翻译：

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隔离预防措施对生活质量的影响：一项荟萃分析。

隔离预防措施对患者心理健康的影响尚未完全量化。评估隔离预防措施对患者健康相关的生活质量和抑郁或焦虑量表的影响，并估算每天的焦虑和抑郁成本。在EMBASE和PubMed数据库以及Google Scholar中搜索了与隔离预防措施的影响有关的文献。对物品进行了两步独立的筛选。包括比较使用不同生活质量和心理负担量表的孤立和非孤立患者的文章。使用医院焦虑和抑郁量表（HADS-A和HADS-D）进行荟萃分析。所选文献中的心理负担测度以效果大小的形式显示在图表中。使用荟萃分析汇总的平均差异估算每天的焦虑和抑郁成本。在106篇文章中，有94篇由于纳入标准而被排除在外，剩下12篇文章需要全文阅读。在对文章全文进行审阅后，入选了七篇文章进行实证分析，其中七篇文章进行了荟萃分析。HADS-A的汇总平均差异估计值为-1.4（P = 0.15），HADS-D的汇总平均差异估计值为-1.85（P = 0.09）。在心理负担量表的实证分析中，除一项研究外，所有研究的结果均为阴性。对心理负担进行荟萃分析和实证分析的结果表明，孤立的患者总体上情况更糟。就质量调整生命年（QALYs）而言，每天焦虑和抑郁的隐含估计成本约为10美元。