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Abnormal X chromosome inactivation and tumor development.
Cellular and Molecular Life Sciences ( IF 7.014 ) Pub Date : 2020-02-10 , DOI: 10.1007/s00018-020-03469-z
Dan Wang,Le Tang,Yingfen Wu,Chunmei Fan,Shanshan Zhang,Bo Xiang,Ming Zhou,Xiaoling Li,Yong Li,Guiyuan Li,Wei Xiong,Zhaoyang Zeng,Can Guo

During embryonic development, one of the two X chromosomes of a mammalian female cell is randomly inactivated by the X chromosome inactivation mechanism, which is mainly dependent on the regulation of the non-coding RNA X-inactive specific transcript at the X chromosome inactivation center. There are three proteins that are essential for X-inactive specific transcript to function properly: scaffold attachment factor-A, lamin B receptor, and SMRT- and HDAC-associated repressor protein. In addition, the absence of X-inactive specific transcript expression promotes tumor development. During the process of chromosome inactivation, some tumor suppressor genes escape inactivation of the X chromosome and thereby continue to play a role in tumor suppression. A well-functioning tumor suppressor gene on the idle X chromosome in women is one of the reasons they have a lower propensity to develop cancer than men, women thereby benefit from this enhanced tumor suppression. This review will explore the mechanism of X chromosome inactivation, discuss the relationship between X chromosome inactivation and tumorigenesis, and consider the consequent sex differences in cancer.
更新日期:2020-02-10

 

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