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Organocatalyzed styrene epoxidation accelerated by continuous-flow reactor
Journal of Flow Chemistry ( IF 2.7 ) Pub Date : 2020-02-10 , DOI: 10.1007/s41981-019-00065-6
Wei-Qiang Yuan , Shou-Quan Zhou , Yu-Yan Jiang , Hao-Hong Li , Hui-Dong Zheng

Considering the low conversion and long reaction time in scaling up reaction in batch reactor, the organocatalyzed epoxidation reaction of styrene was intensified under continuous flow conditions using a commercial fluidic reactor (Corning Advanced Flow G1 Reactor). After investigating the effect of reaction temperature, catalyst amount, MeCN/t-BuOH ratio, FO/FAB (buffer solution amount), total feed flow rate and operating mode on the epoxidation reaction, the optimal reaction conditions were identified under continuous flow conditions. Upon optimization, high conversion and excellent selectivity with short reaction time (3.17 min) can be obtained. We successfully developed a process for the rapid and continuous epoxidation of styrene using an organocatalyst with hydrogen peroxide as the oxidant. Compared with the batch conditions, the continuous flow reactor can exhibit unique advantages including high-speed, safety, continuousness and absence of amplifying effect, which will be significant for the industrial production of epoxides.



中文翻译:

连续流反应器促进有机催化苯乙烯环氧化

考虑到在分批反应器中按比例放大反应的低转化率和长反应时间,使用商业流体反应器(Corning Advanced Flow G1反应器)在连续流动条件下增强了苯乙烯的有机催化环氧化反应。调查反应温度,催化剂量,的MeCN /后的效果-BuOH比率,˚F ø / ˚F AB(缓冲溶液量),总进料流速和环氧化反应的操作方式,在连续流动条件下确定最佳反应条件。经过优化,可以获得高转化率和出色的选择性,且反应时间短(3.17分钟)。我们成功开发了一种使用有机催化剂,以过氧化氢为氧化剂对苯乙烯进行快速连续环氧化的方法。与间歇条件相比,连续流反应器可展现出独特的优势,包括高速,安全,连续性和无放大作用,这对于环氧化物的工业生产将具有重要意义。

更新日期:2020-02-10
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