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pH-responsive nanoparticles based on optimized synthetic amphiphilic poly(β-amino esters) for doxorubicin delivery
Colloid and Polymer Science ( IF 2.4 ) Pub Date : 2020-02-10 , DOI: 10.1007/s00396-020-04606-7
Feng Gao , Qiang Wang , Xiaochun Yang

Synthesis of amphiphilic poly(β-amino esters) (PBAE) was optimized by stepwise feeding of monomers (PBAE-(P-H)) compared with one-pot synthesis (PBAE-(PH PDI, 0.103) than PBAE-(PH PDI, 0.233) demonstrated by dynamic light scattering and transmission electron microscopy. Afterward, PBAE-(P-H) and PBAE-(P&H) nanoparticles were selected to further investigate the properties including charge conversion and pH responsiveness. Doxorubicin (DOX) was encapsulated into nanoparticles. DOX release in vitro was enhanced as the decrease of pH value. Furthermore, DOX-loaded PBAE-(P-H) and PBAE-(P&H) nanoparticles exhibited enhanced cytotoxicity and cellular uptake against HCT116 cells compared with DOX under tumor microenvironment.

中文翻译:

基于优化的合成两亲性聚(β-氨基酯)的 pH 响应纳米粒子,用于阿霉素递送

与一锅法合成(PBAE-(PH PDI,0.103)相比,PBAE-(PH PDI,0.233)通过逐步进料单体(PBAE-(PH))优化了两亲性聚(β-氨基酯)(PBAE)的合成) 通过动态光散射和透射电子显微镜证实。然后,选择 PBAE-(PH) 和 PBAE-(P&H) 纳米粒子进一步研究包括电荷转换和 pH 响应性在内的性质。阿霉素 (DOX) 被封装到纳米粒子中。DOX 释放体外随着pH值的降低而增强,此外,在肿瘤微环境下,与DOX相比,载有DOX的PBAE-(PH)和PBAE-(P&H)纳米颗粒对HCT116细胞的细胞毒性和细胞摄取增强。
更新日期:2020-02-10
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