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Divergent syntheses of spirooxindoles from oxindole-embedded four-membered synthon via cycloaddition reactions
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2020/02/10 , DOI: 10.1039/d0qo00038h
Hongjin Shi 1, 2, 3, 4 , Liang Wang 1, 2, 3, 4, 5 , Shuai-Shuai Li 1, 2, 3, 4, 5 , Yongjun Liu 5, 6, 7, 8 , Lubin Xu 1, 2, 3, 4
Affiliation  

The highly efficient construction of five and six membered heterocycle fused spirooxindoles was achieved via the [4 + 1] and formal [4 + 2] cycloaddition reactions between our rationally designed four-membered synthons and pyridinium methylides and α-bromoacetophenones, respectively. A wide range of richly decorated oxindole-containing chroman, chromen, and 2H-benzofuran derivatives were synthesized in moderate to high yields and diastereoselectivities.

中文翻译:

通过环加成反应从羟吲哚嵌入的四元合成子中合成螺硫辛醇

通过合理设计的四元合成子与吡啶鎓甲基化物和α-溴苯乙酮之间的[4 +1]和正式的[4 + 2]环加成反应,可以高效地构建五元和六元杂环稠合的螺硫辛多。以中等至高收率和非对映选择性合成了种类繁多的装饰丰富的含羟吲哚的苯并二氢吡喃,铬烯和2 H-苯并呋喃衍生物。
更新日期:2020-03-03
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