DNA-encoded library technology (DELT) was introduced to our medicinal chemistry society more than 20 years ago. The application of DELT in the development of clinical candidates has been actively reported in the literature recently. A few representative examples include RIP1K inhibitors for inflammatory diseases and sEH inhibitors for endothelial dysfunction or abnormal tissue repair, among many others. Here, the authors would like to recall the recent developments in on-DNA synthetic methodologies for DEL construction and to analyze recent examples in the literature of DELT-based drug development efforts pursued in both the academic and industrial sectors. With this perspective, we hope to provide a useful summary of recent DELT-based drug discovery research and to discuss the future scope of DELT in medicinal chemistry.

中文翻译：

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DNA编码文库筛选作为药物发现的核心平台技术：其合成方法的开发及其在DEL合成中的应用。

DNA编码文库技术（DELT）于20多年前被引入了我们的药物化学学会。最近在文献中积极报道了DELT在临床候选药物开发中的应用。一些代表性的例子包括用于炎症性疾病的RIP1K抑制剂和用于内皮功能障碍或异常组织修复的sEH抑制剂，等等。在这里，作者想回顾用于DEL构建的On-DNA合成方法的最新发展，并分析学术界和工业界基于DELT的药物开发成果的文献中的最新实例。从这个角度出发，我们希望为基于DELT的最新药物发现研究提供有用的摘要，并讨论DELT在药物化学中的未来范围。