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Preserved Somatosensory Conduction in Complete Spinal Cord Injury: Discomplete SCI
Clinical Neurophysiology ( IF 4.7 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.clinph.2020.01.017
Amar Awad , Richard Levi , Mikael Waller , Göran Westling , Lenita Lindgren , Johan Eriksson

OBJECTIVE Spinal cord injury (SCI) disrupts the communication between brain and body parts innervated from below-injury spinal segments, but rarely results in complete anatomical transection of the spinal cord. The aim of this study was to investigate residual somatosensory conduction in clinically complete SCI, to corroborate the concept of sensory discomplete SCI. METHODS We used fMRI with a somatosensory protocol in which blinded and randomized tactile and nociceptive stimulation was applied on both legs (below-injury level) and one arm (above-injury level) in eleven participants with chronic complete SCI. The experimental design accounts for possible confounding mechanical (e.g. vibration) and cortico-cortical top-down mechanisms (e.g. attention/expectation). RESULTS Somatosensory stimulation on below-level insensate body regions activated the somatotopically corresponding part of the contralateral primary somatosensory cortex in six out of eleven participants. CONCLUSIONS Our results represent afferent-driven cortical activation through preserved somatosensory connections to the brain in a subgroup of participants with clinically complete SCI, i.e. sensory discomplete SCI. SIGNIFICANCE Identifying patients with residual somatosensory connections might open the door for new rehabilitative and restorative strategies as well as inform research on SCI-related conditions such as neuropathic pain and spasticity.

中文翻译:

完全性脊髓损伤中保留的体感传导:不完全性 SCI

目的 脊髓损伤 (SCI) 会扰乱受损伤下方脊髓节段支配的大脑和身体部位之间的交流,但很少导致脊髓完全解剖横断。本研究的目的是调查临床完全性 SCI 中残留的体感传导,以证实感觉不完全性 SCI 的概念。方法我们使用 fMRI 和体感协议,其中对 11 名慢性完全性 SCI 参与者的双腿(低于损伤水平)和一只手臂(高于损伤水平)应用盲法和随机触觉和痛觉刺激。实验设计考虑了可能混杂的机械(例如振动)和皮质-皮质自上而下的机制(例如注意力/期望)。结果 在 11 名参与者中的 6 名中,对低于水平无感觉身体区域的体感刺激激活了对侧初级体感皮层的体感相应部分。结论 我们的结果表明,在具有临床完全性 SCI,即感觉不完全性 SCI 的参与者亚组中,传入驱动的皮层激活通过与大脑保持的躯体感觉连接。意义识别具有残余体感连接的患者可能为新的康复和恢复策略打开大门,并为 SCI 相关疾病(如神经性疼痛和痉挛)的研究提供信息。结论 我们的结果表明,在具有临床完全性 SCI,即感觉不完全性 SCI 的参与者亚组中,传入驱动的皮层激活通过与大脑保持的躯体感觉连接。意义识别具有残余体感连接的患者可能为新的康复和恢复策略打开大门,并为 SCI 相关疾病(如神经性疼痛和痉挛)的研究提供信息。结论 我们的结果表明,在具有临床完全性 SCI,即感觉不完全性 SCI 的参与者亚组中,传入驱动的皮层激活通过与大脑保持的躯体感觉连接。意义识别具有残余体感连接的患者可能为新的康复和恢复策略打开大门,并为 SCI 相关疾病(如神经性疼痛和痉挛)的研究提供信息。
更新日期:2020-05-01
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