The heterogeneous hydrolysis of dinitrogen pentoxide (N₂O₅) plays an important role in regulating NO_x. The N₂O₅ uptake coefficient, γ(N₂O₅), was determined using an iterative box model that was constrained to observational data obtained in suburban Beijing from February to March 2016. The box model determined 2289 individual γ(N₂O₅) values that varied from <0.001 to 0.02 with an average value of 0.0046 ± 0.0039 (and a median value of 0.0032). We found the derived winter γ(N₂O₅) values in Beijing were relatively low as compared to values reported in previous field studies conducted during winter in Hong Kong (average value of 0.014) and the eastern U.S. coast (median value of 0.0143). In our study, field evidence of the suppression of γ(N₂O₅) values due to pNO₃⁻ content, organics and the enhancement by aerosol liquid water content (ALWC) is in line with previous laboratory study results. Low ALWC, high pNO₃⁻ content, and particle morphology (inorganic core with an organic shell) accounted for the low γ(N₂O₅) values in the North China Plain (NCP) during wintertime. The field-derived γ(N₂O₅) values are well reproduced by a revised parameterization method, which includes the aerosol size distribution, ALWC, nitrate and organic coating, suggesting the feasibility of comprehensive parameterization in the NCP during wintertime.