A wide range of methods for the enantioselective synthesis of α‐aminophosphonic acid derivatives have been developed over the years. Although the most used methodology is the Pudovik reaction, the use of α‐iminophosphonates for the synthesis of optically active α‐aminophosphonates has emerged during the last years. The existing methods for the synthesis of α‐phosphorylated imines and their enantioselective reactions for the synthesis of enantio‐enriched α‐aminophosphonates are summarized in this review.

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α-氨基膦酸酯：α-氨基膦酸酯对映选择性合成的有用中间体

多年来，开发了多种对映选择性合成α-氨基膦酸衍生物的方法。尽管最常用的方法是Pudovik反应，但在最近几年中出现了使用α-亚氨基膦酸酯合成旋光性α-氨基膦酸酯的方法。本文综述了合成α-磷酸化亚胺的现有方法及其对映体选择性反应，以合成对映体富集的α-氨基膦酸酯。