Identifying indicators of response to immunotherapy is key for treatment decisions. Two studies now report that early changes in T cell repertoires and CD8+ memory effector cytotoxic T cells in peripheral blood correlate with response to immune-checkpoint inhibitors in metastatic melanoma and may serve as actionable biomarkers of immune activation.

中文翻译：

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跟踪对免疫疗法的早期反应

确定对免疫治疗反应的指标是治疗决策的关键。现在有两项研究报告说，外周血中 T 细胞库和 CD8+ 记忆效应细胞毒性 T 细胞的早期变化与转移性黑色素瘤对免疫检查点抑制剂的反应相关，并可能作为免疫激活的可操作生物标志物。